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What genetic factors are relevant to developing depression?

Dra. Sara Siddi
Dra. Sara Siddi
Psychologist and Doctor of Clinical Neuroscience. Department of Teaching, Research and Innovation
Parc Sanitari Sant Joan de Déu

Depression, like most disorders that affect humans, has both a genetic and an environmental component. There are some genes that appear to increase the risk of developing the disorder, but they always act in conjunction with other genes and environmental factors.

It appears that the serotonin transporter gene and genes involved in the serotonergic system , whose functions include regulating wakefulness, emotional and sexual behaviors, food intake and vomiting, pain perception and muscle tone, are candidates for susceptibility to depression, given that many antidepressant drugs act on these systems.

Serotonin is known as the happiness hormone ; low levels of serotonin in the body are associated with depression, fatigue, negative attitude, irritability, mood swings, difficulty controlling anger, insomnia, difficulty concentrating, anxiety, and uncontrollable emotional changes.

We must always keep in mind that the environment is very important and there may be triggering factors such as some trauma (loss or others) that can favor the appearance of depression.

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Dra. Sara Siddi
Dra. Sara Siddi
Psychologist and Doctor of Clinical Neuroscience. Department of Teaching, Research and Innovation
Parc Sanitari Sant Joan de Déu
Emilio José Pérez
Emilio José Pérez
Person with personal experience of depression